- Underwear Accessories[5]
- Bras[2]
- Car DVD Player[1]
- Car PC[10]
- Facial Steamer[1]
- Multi-Functional Beauty Equipment[10]
- Breast Form[3]
- Nursing Pad[1]
- Toothbrush[10]
- Organic Intermediate[1]
- Earphones & Headphones[2]
- Christmas Decoration Supplies[6]
- Emergency & Clinics Apparatus[4]
- General Assay & Diagnostic Apparatus[10]
- Ultrasonic[5]
- Ward Nursing Equipments[1]
- Bar Tools[1]
- Detergent[2]
- Other Household Sundries[2]
- Laundry Balls & Discs[3]
- Other Laundry Products[3]
- Pet Toys[9]
- Cups & Saucers[1]
- Vacuum Flasks & Thermoses[1]
- Water Pots & Kettles[1]
- Other Water Treatment Appliances[1]
- Water Dispensers[10]
- Water Filters[10]
- Cosmetic Bags & Cases[10]
- PH Meters[8]
- Temperature Instruments[1]
- Testing Equipment[2]
- Wristwatches[5]
- Contact Person : Ms. Jiang Karen
- Company Name : Shenzhen Huge Creation Technology Limited
- Tel : 86-755-83586771
- Fax : 86-755-83828772
- Address : Guangdong,Shenzhen,Rm C02-04, 7th floor, C&D seats, Tianji Building, Tian'an Cyber Park, Futian District
- Country/Region : China
- Zip : 518042
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Wholesale of Linezolid
Linezolid is a synthetic antibiotic used for the treatment of serious infections caused by Gram-positive bacteria that are resistant to several other antibiotics. A member of the oxazolidinone class of drugs, linezolid is active against most Gram-positive bacteria that cause disease, including streptococci, vancomycin-resistant enterococci (VRE), and methicillin-resistant Staphylococcus aureus (MRSA).[1] The main indications of linezolid are infections of the skin and soft tissues and pneumonia (particularly hospital-acquired pneumonia), although off-label use for a variety of other infections is becoming popular. Linezolid is marketed by Pfizer under the trade names Zyvox (in the United States, United Kingdom, Australia, and several other countries), Zyvoxid (in Europe), and Zyvoxam (in Canada and Mexico). Generics are also available in India, such as Linospan (Cipla)..
Discovered in the 1990s and first approved for use in 2000, linezolid was the first commercially available 1,3-oxazolidinone antibiotic. As of 2009[update], it is the only marketed oxazolidinone, although others are in development. As a protein synthesis inhibitor, it stops the growth of bacteria by disrupting their production of proteins. Although many antibiotics work this way, the exact mechanism of action of linezolid appears to be unique to the oxazolidinone class. Bacterial resistance to linezolid has remained very low since it was first detected in 1999, although it may be increasing.
When administered for short periods, linezolid is a relatively safe drug; it can be used in patients of all ages and in people with liver disease or poor kidney function. Common adverse effects of short-term use include headache, diarrhea, and nausea. Long-term use, however, has been associated with serious adverse effects; linezolid can cause bone marrow suppression and low platelet counts, particularly when used for more than two weeks. If used for longer periods still, it may cause peripheral neuropathy (which can be irreversible), optic nerve damage, and lactic acidosis (a buildup of lactic acid in the body), all most likely due to mitochondrial toxicity.
Medical usesThe main indication of linezolid is the treatment of severe infections caused by Gram-positive bacteria that are resistant to other antibiotics; it should not be used against bacteria that are sensitive to drugs with a narrower spectrum of activity, such as penicillins and cephalosporins. In both the popular press and the scientific literature, linezolid has been called a "reserve antibiotic"—one that should be used sparingly so that it will remain effective as a drug of
last resort against potentially intractable infections. In the United States, the FDA-approved indications for linezolid use are: vancomycin-resistant Enterococcus infection, with or without bacterial invasion of the bloodstream; hospital- and community-acquired pneumonia caused by S. aureus or S. pneumoniae; complicated skin and skin structure infections (cSSSI) caused by susceptible bacteria, including diabetic foot infection, unless complicated by osteomyelitis (infection of the bone and bone marrow); and uncomplicated skin and soft tissue infections caused by S. pyogenes or S. aureus. The manufacturer advises against the use of linezolid for community-acquired pneumonia or uncomplicated skin and soft tissue infections caused by MRSA.[1] In the United Kingdom, pneumonia and cSSSIs are the only indications noted in the product labeling.[6] Linezolid appears to be as safe and effective for use in children and newborns as it is in adults.
Wholesale of Linezolid